The Science of Aging and the Benefits of NMN Supplementation - Varalife®

The Science of Aging and the Benefits of NMN Supplementation


Role of NAD+ in Aging

Low NAD+ Levels and Aging

Tested through Human Trials

NMN Supplementation as an Anti-Aging Strategy


  1. Soma, M., Lalam, S.K. The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.  49, 9737–9748 (2022).
  2. Cui H, Kong Y, Zhang H (2012) Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012:646354.
  3. Leadsham JE, Sanders G, Giannaki S, Bastow EL, Hutton R, Naeimi WR, Breitenbach M, Gourlay CW (2013) Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast. Cell Metab 18(2):279–286.
  4. Nicolson GL (2014) Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Integr Med (Encinitas) 13(4):35–43
  5. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021 Jul 8;18(1):54. doi: 10.1186/s12970–021–00442–4. PMID: 34238308; PMCID: PMC8265078.
  6. Kimura S, Ichikawa M, Sugawara S, et al. (September 05, 2022) Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals. Cureus 14(9): e28812. DOI 10.7759/cureus.28812
  7. Yi, L., Maier, A.B., Tao, R.  The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.  45, 29–43 (2023).
  8. Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10(1):5284.
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